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Student Profiles:
Christopher

Christopher T. Whitlow, MD, PhD



Matriculated: 1998

Graduate Program: Physiology & Pharmacology

Education:

1. UNDERGRADUATE EDUCATION:

...College:
...East Carolina University
...Greenville, North Carolina
...BA in Psychology, Magna Cum Laude (1997)


2. MEDICAL EDUCATION:

...M.D./Ph.D. Program (1998-2004):
...Wake Forest University School of Medicine
...Winston-Salem, North Carolina
...Doctor of Medicine
...Doctor of Philosophy


3. POSTDOCTORAL TRAINING:

...Internship (7/04-6/05):
...Internal Medicine
...Moses Cone Memorial Hospital
...Greensboro, North Carolina

...Residency (7/05-6/09):
...Diagnostic Radiology
...Wake Forest University Baptist Medical Center
...Winston-Salem, North Carolina

...Fellowship (7/09-7/10):
...Neuroradiology
...Wake Forest University Baptist Medical Center
...Winston-Salem, North Carolina

4. PROFESSIONAL POSITIONS:

...Assistant Professor, Radiology (7/10 - Current):
...Neuroradiology
...Wake Forest University Baptist Medical Center
...Winston-Salem, North Carolina

...Program Director (7/12 - Current):
...MD/PhD Program
...Wake Forest University School of Medicine
...Winston-Salem, North Carolina

Research:
1. DOCTORAL DISSERTATION ABSTRACT

Neuroanatomical substrates and cognitive effects of cannabinoids: A translational neuroimaging approach.

Doctoral Dissertation under the direction of: Linda J. Porrino, Ph.D., Professor of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston-Salem, N.C. May 2003.


Cannabinoid receptors are among the most abundant in brain, with densities rivaling that of GABA- and glutamate-gated ion channels. Little is know, however, about the role of this neurotransmitter-receptor system on brain function and behavior. The present series of studies was designed to further characterize the effects of cannabinoids using a translational model, with the goal of using data from initial laboratory animal studies to guide subsequent investigations in human subjects.

The first aim of these studies was to determine the primary neuroanatomical substrates affected by the cannabinoid, delta 9-tetrahydrocannabinol (THC), using the quantitative 2-[14C]deoxyglucose method in a well controlled laboratory animal model of cannabis exposure. The administration of THC to rodents produced persistent changes in central nervous system (CNS) functional activity in portions of the limbic forebrain (e.g., infralimbic cortex, anterior cingulate, and basolateral amygdala), suggesting possible cannabinoid-associated alterations in behaviors subserved by these structures (e.g., anxiety, stress, and reward). Few studies, however, have addressed such changes among humans with chronic cannabinoid exposure (marijuana users).

A series of translational experiments, therefore, was designed to determine if humans with chronic cannabinoid exposure exhibit evidence of limbic-associated alterations of cognitive function. Consistent with our hypothesis, chronic marijuana users performed poorly on a task (The Gambling Task) thought to access limbic-related areas of the CNS. A final series of studies utilized functional magnetic resonance imaging (fMRI) to determine if chronic cannabinoid exposure results in activation of a different pattern of CNS substrates during performance of The Gambling Task. Indeed, individuals with heavy long-term cannabinoid exposure exhibited task-associated blood oxygen level dependent (BOLD) signal decreases in the anterior cingulate, as compared to controls. Furthermore, activation of anterior cingulate cortex was found to be positively correlated with gambling task performance, suggesting that the anterior cingulate and other limbic alterations observed in the rodent model may have true functional significance for humans.

Taken together, these studies are important because they identify a particularly robust difference in limbic-related processes among individuals with a history of heavy cannabinoid exposure, which adds to the current focus of cannabis research on aspects of learning, memory and executive function. Furthermore, these data demonstrate the utility of combining multiple complementary levels of analysis, using both laboratory animals and human subjects to fully explore the CNS effects of a drug. Although there is certainly not perfect homology between laboratory animals and human subjects, such translational approaches can guide the kinds of questions that may help elucidate important aspects of neuropharmacological agents in humans.



2. RSNA R & E FOUNDATION RESEARCH RESIDENT GRANT ABSTRACT

Percutaneous femoroplasty for preventing hip fracture: Procedural development and finite element analysis.

RSNA R & E Foundation Research Resident Grant under the direction of: P. Pearse Morris, M.B., B.Ch., Associate Professor of Radiology, Medical Alliance Director Interventional and Neuroradiology, Wake Forest University School of Medicine, Winston-Salem, N.C. May 2003.

Osteoporosis affects millions of individuals worldwide, and has no cure. Hip fracture is a devastating complication of osteoporosis that is associated with high morbidity and mortality. Relatively costly medical therapies to prevent osteoporotic fracture have variable efficacy, and surgical interventions post fracture can result in significant peri-operative complications and difficult prolonged recovery periods. Estimated Medicare costs for hip fracture approaches $3 billion annually.

The present proposal aims to develop and investigate a new relatively inexpensive minimally invasive image guided procedure for preventing hip fractures due to falls. We hypothesize that augmentation of osteoporotic femoral necks by controlled economic delivery of polymethylmethacrylate bone-cement, termed femoroplasty, will be mechanically effective in reducing stresses in the femoral neck under fall conditions.

To test this hypothesis, percutaneous femoroplasty will be performed on osteoporotic cadaveric femurs. Biomechanical strain gage measurement of femoroplasty treated and matched non-treated controls will be conducted in a configuration simulating fall on the greater trochanter. Finite element (FE) models will then be constructed from CT scans obtained before and after femoroplasty that permit differentiation of cortical and trabecular bone in accordance with variations of the bone mineral density. FE analysis of these models will be performed using computer program solvers to further characterize the biomechanical performance of femurs with and without femoroplasty.

The significance of our project is that it aims to advance the possibility of introducing a practical and inexpensive minimally invasive prophylactic procedure for prevention of hip-fracture, using currently available technology. The procedural steps involved rely completely on currently available skills and devices, while the target population is manifestly underserved for want of effective interventions. Many who are at risk for the devastating consequences of hip fracture would benefit from an effective, minimally invasive, and inexpensive treatment that addresses this important problem.

Presentations:
PUBLISHED ABSTRACTS:

1. Rawls SM, Whitlow CT, Church WH, McGinty JF. Kappa opioid receptor agonist blocks potassium-
....stimulated increase in extracellular glutamate levels in rat striatum. Society for Neuroscience 25th
....Annual Meeting, 1995, San Diego, California.

2. Porrino LJ, Whitlow CT, Miller MD, Grant KA. Neuroanatomical substrates underlying the discrimination
....of ethanol from water. Research Society on Alcoholism 20th Annual Meeting, 1997, San Francisco,
....California.

3. Letchworth SR, Smith HR, Hart SL, Allen JW, Whitlow CT, Davies HML, Childers SR, Porrino LJ. The
....novel cocaine analog, [3H]PTT, as a functional marker of the dopamine transporter. Society for
....Neuroscience 27th Annual Meeting, 1997, New Orleans, Louisiana.

4. Whitlow CT & Porrino LJ. Contribution of 5-HT3 activity to the effects of ethanol on rates of local
....cerebral glucose utilization in rats. Research Society on Alcoholism 21st Annual Meeting, 1998,
....Hilton Head, South Carolina.

5. Porrino LJ & Whitlow CT. Metabolic mapping of the time-dependent effects of Delta9-
....tetrahydrocannabinol in rats. International Cannabinoid Research Society, 8th Annual Symposium on
....the Cannabinoids, 1998, La Grande-Motte, France.

6. Porrino LJ & Whitlow CT. Effects of D1 and D2 antagonists on the functional consequences of ethanol
....in rats. Society for Neuroscience 28th Annual Meeting, 1998, Los Angeles, California.

7. Freedland CS, Whitlow CT, Hart SL, Porrino LJ. Effects of Delta9-tetrahydrocannabinol on local
....cerebral glucose utilization. Society for Neuroscience 29th Annual Meeting, 1999, Miami Beach, Florida.

8. Freedland CS, Whitlow CT, Hart SL, Porrino LJ. Effects of Delta9-tetrahydrocannabinol on local
....cerebral glucose utilization. International Cannabinoid Research Society, 9th Annual Symposium on
....the Cannabinoids, 1999, Acapulco, Mexico.

9. Whitlow CT, Freedland CS, Porrino LJ. Persistent effects of the acute administration of Delta9-
....tetrahydrocannabinol on rates of local cerebral glucose utilization in the rat. Wake Forest
....University School of Medicine Annual Medical Student Research Day, 1999, Winston Salem, North
....Carolina.

10. Freedland CS, Whitlow CT, Williams LA, Miller M, Porrino LJ. Dose-related effects of Delta9-
.....tetrahydrocannabinol on local cerebral glucose utilization. Society for Neuroscience 30th Annual
.....Meeting, 2000, New Orleans, Louisiana.

11. Freedland CS, Whitlow CT, Miller MD, Porrino LJ. (2001) Effects of SR141716A on rates of local
.....cerebral glucose utilization. International Cannabinoid Research Society, 11th Annual Symposium on
.....the Cannabinoids, 2001, San Lorenzo de El Escorial, Spain.

12. Freedland CS, Whitlow CT, Miller MD, Porrino LJ. Metabolic mapping of the effects of the acute
.....administration of the cannabinoid receptor antagonist SR141716A in rat. Society for Neuroscience
.....31st Annual Meeting, 2001, San Diego, California.

13. Whitlow CT, Freedland CS, Miller MD, Porrino LJ. Chronic effects of Delta9-tetrahydrocannabinol on
.....rates of local cerebral glucose utilization in rats. International Cannabinoid Research Society, 11th
.....Annual Symposium on the Cannabinoids, 2001, San Lorenzo de El Escorial, Spain.

14. Whitlow CT, Freedland CS, Porrino LJ. Functional consequences of the repeated administration of
.....Delta9-tetrahydrocannabinol. Society for Neuroscience 31st Annual Meeting, 2001, San Diego,
.....California.

15. Lamborne CM, Whitlow CT, Freedland CS, Porrino L.J. Effects of CP55,940 on rates of local cerebral
.....glucose utilization in the rat. The College on Problems of Drug Dependence 64th Annual Meeting,
.....2002, Quebec, Canada.

16. Whitlow CT, Livengood LB, Hart SL, Lamborn CM, Liguori A, Frasca TA, Laurienti PJ, Porrino LJ. Long-
.....term cannabis users employ different decision-making strategies than controls in a risk-taking task.
.....Society for Neuroscience 32nd Annual Meeting, 2002, Orlando, Florida.

17. Lamborn CM, Whitlow CT, Laurienti PJ, Liguori A, Livengood LB, Hart SL, Porrino LJ. Decision-making
.....in heavy marijuana users: an fMRI study. The College on Problems of Drug Dependence 65th Annual
.....Meeting, 2003, Bal Harbour Florida.

18. Whitlow CT, Sinclair ML, David RR, McGregor JG, Soler ZM, Tipton JS, Walker F.O. (2003) Magnetic
.....Resonance Imaging of brain and muscle in a case of ecstasy (methylenedixoymethamphetamine
.....{MDMA}) related neuroleptic malignant syndrome. American Society of Neuroimaging 26th Annual
.....Meeting, 2003, New Orleans, Louisiana.

19. Whitlow CT, Reedy ML, Cotton JR, Kaminsky SE, Berry JL, Morris PP. (2004) Investigating
.....sacroplasty: Technical considerations and biomechanical properties of sacral polymethylmethacrylate
.....infusions in cadaveric pelvic specimens. Radiological Society of North America's 90th Scientific
.....Assembly and Annual Meeting, 2005, Chicago, Illinois.

20. Morris P, Tegeler C, O'Donovan CA, Meads D, Kim J, Whitlow CT. Utility of transcranial doppler
.....monitoring during wada testing and potential applications to therapeutic endovascular procedures.
.....American Society of Neuroradiology 43rd Annual Meeting, 2005, Toronto, Ontario.

21. Whitlow CT, Eberhardt AW, Yazdani SK, Reedy ML, Berry JL, Morris PP. Fluoroscopy-guided
.....percutaneous injection of polymethylmethacrylate into cadaveric hip: A possible prophylactic
.....treatment for individuals at risk for hip fracture. Radiological Society of North America's 91st
.....Scientific Assembly and Annual Meeting, 2005, Chicago, Illinois.

22. Mattern CWT, Whitlow CT, Mussat-Whitlow BJ, Reedy ML, Baker MD, Morris P. Sacroplasty versus
.....vertebroplasty: Comparable clinical efficacy for the treatment of fracture-related pain. American
.....Society of Neuroradiology 44th Annual Meeting, 2006, San Diego, California.

23. Morris P, Berry J, Geer C, Mattern C, Whitlow CT, Yazdani S, Lalli J, Claus R, Challa V. Ultra-thin
.....gold and vitronectin coating on platinum show enhanced neointimal response compared with
.....platinum in a rat aneurysm model. American Society of Neuroradiology 45th Annual Meeting,
.....2007, Chicago, Illinois.

24. Whitlow CT, Pollock JM, Kraft RA, Mussat-Whitlow BJ, Tan H, Burdette JH, Maldjian JA. Age-related
.....changes in global rates of cerebral perfusion in normal children, adolescents, and young adults: A
.....magnetic resonance arterial spin labeling investigation. American Society of Functional Neuroradiology
.....2nd Annual Meeting, 2008, Orlando, Florida.

25. Whitlow CT, Pollock JM, Kraft RA, Mussat-Whitlow BJ, Tan H, Burdette JH, Maldjian JA. Time-
.....dependent changes in cerebral perfusion associated with posterior reversible encephalopathy: A
.....magnetic resonance arterial spin labeling investigation. American Society of Functional Neuroradiology
.....2nd Annual Meeting, 2008, Orlando, Florida.

26. Pollock JM, Whitlow CT, Deibler AR, Burdette JH, Kraft RA, Tan H, Maldjian JA. Anoxic injury
.....associated cerebral hyperperfusion identified with arterial spin labeled MR imaging. American
.....Society of Neuroradiology 46th Annual Meeting, 2008, New Orleans, Louisiana.

27. Whitlow CT, Pollock JM, Mussat-Whitlow BJ, Kraft RA, Tan H, Burdette JH, Maldjian JA. Changes in
.....global rates of cerebral perfusion associated with normal development as measured with MR arterial
.....spin labeling. American Society of Neuroradiology 46th Annual Meeting, 2008, New Orleans,
.....Louisiana.

28. Whitlow CT, Pollock JM, Mussat-Whitlow BJ, Kraft RA, Tan H, Burdette JH, Maldjian JA. Temporal
.....changes in cerebral perfusion associated with posterior reversible encephalopathy syndrome as
.....measured with MR arterial spin labeling. American Society of Neuroradiology 46th Annual Meeting,
.....2008, New Orleans, Louisiana.

29. Whitlow CT, Geer C, Mattern CW, Mussat-Whitlow BJ, Yazdani S, Berry JL, Challa V, Morris PP.
.....Endovascular histologic effects of ultra-thin gold coated platinum coil in a rodent model of saccular
.....aneurysm: A preliminary investigation. Radiological Society of North America's 94th Scientific
.....Assembly and Annual Meeting, 2008, Chicago, Illinois.

30. Whitlow CT, Pollock JM, Mussat-Whitlow BJ, Kraft RA, Tan H, Burdette JH, Maldjian JA. Age-related
.....changes in global rates of cerebral perfusion from birth to age 92: A magnetic resonance arterial
.....spin labeling investigation. Radiological Society of North America's 94th Scientific Assembly
.....and Annual Meeting, 2008, Chicago, Illinois.

31. Pollock JM, Deibler AR, Whitlow CT, Tan H, Kraft RA, Burdette JH, Maldjian JA. Hypercapnia-induced
.....cerebral hyperperfusion with arterial spin labeled MR imaging perfusion imaging: An underrecognized
.....clinical entity. American Society of Neuroradiology 47th Annual Meeting, 2009, Vancouver,
.....British Columbia, Canada.

32. Whitlow CT, Pollock JM, Kraft RA, Tan H, Burdette JH, Maldjian JA. Pulsed arterial spin-Labeled MR
.....imaging evaluation of tuberous sclerosis. American Society of Neuroradiology 47th Annual Meeting,
.....2009, Vancouver, British Columbia, Canada.

33. Whitlow CT, Tchelepi HA, Grant EG, Matcuk GR. Effect of constant angle insonation versus varied
.....angle insonation on measurement of Doppler velocities. Radiological Society of North America's
.....95th Scientific Assembly and Annual Meeting, 2009, Chicago, Illinois.

Publications:
JOURNAL ARTICLES:

1. Porrino LJ, Williams-Hemby L, Whitlow C, Bowen C, Samson HH. Metabolic mapping of the effects of
....oral alcohol self-administration in rats. Alcohol Clin Exp Res 1998;22:176-82.

2. Lyons D, Whitlow CT, Smith HR, Porrino LJ. Brain imaging. Functional consequences of ethanol in the
....central nervous system. Recent Dev Alcohol 1998;14:253-84.

3. Porrino LJ, Whitlow CT, Samson HH. Effects of the self-administration of ethanol and ethanol/sucrose
....on rates of local cerebral glucose utilization in rats. Brain Res 1998;791:18-26

4. Lyons D, Whitlow CT, Porrino LJ. Multiphasic consequences of the acute administration of ethanol on
....cerebral glucose metabolism in the rat. Pharmacol Biochem Behav 1998;61:201-6.

5. Whitlow CT, Freedland CS, Porrino LJ. Metabolic mapping of the time-dependent effects of Delta9-
....tetrahydrocannabinol administration in the rat. Psychopharmacology (Berl) 2002;161:129-36.

6. Freedland CS, Whitlow CT, Miller MD, Porrino LJ. Dose-dependent effects of Delta9-
....tetrahydrocannabinol on rates of local cerebral glucose utilization in rat. Synapse 2002;45:134-42.

7. Freedland CS, Whitlow CT, Smith HR, Porrino LJ. Functional consequences of the acute administration
....of the cannabinoid receptor antagonist, SR141716A, in cannabinoid-naive and -tolerant animals: a
....quantitative 2-[14C]deoxyglucose study. Brain Res 2003;962:169-79.

8. Whitlow CT, Freedland CS, Porrino LJ. Functional consequences of the repeated administration of
....Delta9-tetrahydrocannabinol in the rat. Drug Alcohol Depend 2003;71:169-77.

9. Macey DJ, Rice WN, Freedland CS, Whitlow CT, Porrino LJ. Patterns of functional activity associated
....with cocaine self-administration in the rat change over time. Psychopharmacology (Berl)
....2004;172:384-92.

10. Whitlow CT, Liguori A, Livengood LB, Hart SL, Mussat-Whitlow BJ, Lamborn CM, Laurienti PJ,
.....Porrino LJ. Long-term heavy marijuana users make costly decisions on a gambling task. Drug
.....Alcohol Depend
2004;76:107-11.

11. Whitlow CT, Yazdani SK, Reedy ML, Kaminsky SE, Berry JL, Morris PP. Investigating sacroplasty:
.....technical considerations and finite element analysis of polymethylmethacrylate infusion into
.....cadaveric sacrum. AJNR Am J Neuroradiol 2007;28:1036-41.

12. Whitlow CT, Mussat-Whitlow BJ, Mattern CW, Baker MD, Morris PP. Sacroplasty versus
.....vertebroplasty: comparable clinical outcomes for the treatment of fracture-related pain. AJNR Am
.....J Neuroradiol
2007;28:1266-70.

13. Pollock JM, Whitlow CT, Deibler AR, Tan H, Burdette JH, Kraft RA, Maldjian JA. Anoxic injury-
.....associated cerebral hyperperfusion identified with arterial spin-labeled MR imaging. AJNR Am J
.....Neuroradiol 2008;29:1302-7.

14. Whitlow CT, Geer C, Mattern CWT, Mussat-Whitlow BJ, Yazdani SK, Berry JL, Lalli JH, Claus RO,
.....Challa VR, Morris PP. Endovascular histologic effects of ultra-thin gold or vitronectin coated platinum
.....aneurysm coil in a rodent arterial occlusion model: A preliminary investigation. AJNR Am J
.....Neuroradiol 2009;30:85-90.

15. Pollock JM, Whitlow CT, Deibler AR, Burdette JH, Kraft RA, Tan H, Maldjian JA. Hypercapnic cerebral
.....hyperperfusion: An unrecognized clinical entity. AJNR Am J Neuroradiol 2009;30:378-85.

16. Pollock JM, Whitlow CT, Deibler AR, Burdette JH, Kraft RA, Tan H, Maldjian JA. Pulsed arterial spin
.....labeled MRI evaluation of tuberous sclerosis. AJNR Am J Neuroradiol 2009;30:815-20.

17. Pollock JM, Tan H, Kraft RA, Whitlow CT, Burdette JH, Maldjian JA. Arterial spin-labeled MR perfusion
.....imaging: Clinical applications. Magn Reson Imaging Clin N Am 2009;17:315-38.

18. Lyders EM, Whitlow CT, Morris PP. Imaging and treatment of sacral insufficiency fractures.
.....AJNR Am J Neuroradiol 2009;In Press.

19. Pollock JM, Whitlow CT, Tan H, Kraft RA, Burdette JH, Maldjian JA. Quantification of arterial venous
.....malformations with arterial spin labeled MRI. AJNR Am J Neuroradiol 2009;Submitted.

20. Whitlow CT, Eberhardt, AE, Berry JL, Morris PP. Simulated femoroplasty using small volume
.....polymethylmethacrylate columns increases force to fracture synthetic osteoporotic
.....femurs. AJR;In Preparation.

21. Whitlow CT, Pollock JM, Mussat-Whitlow BJ, Kraft RA, Tan H, Burdette JH, Maldjian JA. Changes in
.....global rates of cerebral perfusion associated with normal development as measured with magnetic
.....resonance arterial spin labeling. Radiology;In Preparation.

22. Whitlow CT, Pollock JM, Mussat-Whitlow BJ, Kraft RA, Tan H, Burdette JH, Maldjian JA. Temporal
.....changes in cerebral perfusion associated with posterior reversible encephalopathy syndrome as
.....measured with magnetic resonance arterial spin labeling. AJNR Am J Neuroradiol;In Preparation.


Book Chapters:

1. Pollock JM, Tan H, Kraft RA, Whitlow CT, Burdette JH, Maldjian JA. Arterial spin labeled MRI perfusion
.....imaging: Clinical applications. Magn Reson Imaging Clin N Am 2009;17:315-38.

2. Chen MYM, Whitlow CT. Scope of Diagnostic Imaging. In: Chen MYM, Pope TL Jr., Ott DJ. Basic
.....Radiology, Lange Series, New York, McGraw Hill, 2009: In Press.

3. Whitlow CT, OShea TM. Neonatal Neuroimaging. In: Bhatia JS, Mathew OP. Innovations in
.....Neonatal-Perinatal Care: In Press.


OTHER PUBLISHED WORK:

1. Whitlow CT. Recent findings reported at the 11th annual meeting of the International Cannabinoid
....Research Society. Newsletter of the International Cannabinoid Research Society 2002;11: 4-6

2. Whitlow CT, Livengood LB, Hart SL, Lamborn CM, Liguori A, Frasca TA, Laurienti PJ, Porrino LJ. Long-
....term cannabis users employ different decision-making strategies than controls in a risk-taking task.
....Society for Neuroscience 32nd Annual Meeting, 2002, Press Release.

3. Whitlow CT. Mantle. Oil glaze on canvas (121.9 x 91.4 cm). JAMA 2004;291:1639-40.

Honors and Awards:
1994.................University Book Exchange Scholarship, East Carolina University

1997.................Magna cum laude with honors in Psychology, East Carolina University

1998.................M.D./Ph.D. Academic Scholarship, WFU School of Medicine

1998-2004.........National Institutes of Health NRSA M.D./Ph.D. Predoctoral Fellowship Grant

1999.................Medical Student Research Day Poster Award, WFU School of Medicine

2000-2002.........President, Student Interest Group in Neurology, WFU School of Medicine

2001.................NIDA Travel Award: ICRS Annual Meeting; Madrid, Spain

2003.................Alpha Omega Alpha Honor Medical Society

2004.................Published Art: Mantle. Oil glaze on canvas. JAMA 2004;291:1639-1640.

2004.................Richard L. Burt Research Achievement Award, WFU School of Medicine

2004.................I. Meschan Radiology Merit Award, WFU School of Medicine

2004.................Medical Student Prize for Excellence in Neurology, American Academy of Neurology

2006.................Introduction to Research Program, Radiological Society of North America, Chicago, IL

2007.................Presidents Circle R & E Foundation Research Resident Grant, Radiological Society of
........................North America

2007.................Editorial Fellowship for Trainees, Radiological Society of North America

2008.................Invited to attend RSNA Annual Publications Council Meeting with Dr. Herbert Kressel,
........................Editor-in-chief Radiology and Dr. William Olmstead, Editor-in-chief RadioGraphics

2008.................Radiological Society of North America Manuscript Reviewer Mentorship Program.
........................Mentor: Michael H. Lev, MD, Associate Professor of Radiology, Harvard Medical School;
........................Director of Neuro CT, NeuroVascular Laboratory, and Emergency Neuroradiology

2008.................American Society of Functional Neuroradiology Poster Award: Time-dependent changes
........................in cerebral perfusion associated with posterior reversible encephalopathy: A magnetic
........................resonance arterial spin labeling investigation
.

2008.................Roentgen Resident Research Award, Radiological Society of North America
........................Research & Education Foundation

2008.................Derek Harwood-Nash Award in Pediatric Neuroradiology Research, American Society
........................of Neuroradiology & American Society of Pediatric Neuroradiology

2009.................American Society of Neuroradiology (ASNR) Bayer/Neuroradiology Education & Research
........................Foundation Fellowship in Basic Science Research

2009.................Elias G. Theros, M.D. Research Award, Department of Radiology, WFU School of Medicine


RESEARCH SUPPORT:

1. National Institutes of Health (NIH) National Research Service Award M.D./Ph.D. Predoctoral
....Fellowship Grant.
........Title: Neuroanatomical substrates and cognitive effects of cannabinoids: A translational
........neuroimaging approach
.
........Funding period: August 1998 to June 2004.
........NIH Grant Number: F30 DA05911 ($280,000)
........Principal Investigator: Christopher T. Whitlow

2. Radiological Society of North America (RSNA) R & E Foundation Research Resident Grant.
........Title: Percutaneous femoroplasty for preventing hip fracture: Procedural development and finite
........element analysis
.
........Funding period: July 2007 to June 2008.
........RSNA Grant Number: RR0724 ($30,000)
........Principal Investigator: Christopher T. Whitlow, M.D., Ph.D.

3. American Society of Neuroradiology (ASNR) Bayer/Neuroradiology Education & Research Foundation
....Fellowship in Basic Science Research.
........Title: Evolving Patterns of Functional Connectivity in the Developing Brain: An Arterial Spin Labeling
........Perfusion MRI and Computational Network Analytical Investigation
.
........Funding period: July 2009 to June 2010.
........ASNR Grant Number: ....... ($60,000)
........Principal Investigator: Christopher T. Whitlow, M.D., Ph.D.



PROFESSIONAL APPOINTMENTS:

Editorial work:

Manuscript Reviewer for Radiology

Manuscript Reviewer for RadioGraphics

Neuroradiology Educational Exhibit Reviewer for RadioGraphics at Radiological Society of North America Annual Meeting.

Professional Society Memberships:
Alpha Omega Alpha Honor Medical Society

American Medical Association

Radiological Society of North America

American Roentgen Ray Society

American Academy of Neurology

International Society of Cerebral Blood Flow and Metabolism

International Cannabinoid Research Society

Society for Neuroscience

Interests & Hobbies:
INTERESTS:

Painting: Published artwork--Mantle. Oil glaze on canvas (121.9 x 91.4 cm); JAMA. 2004;291:1639-1640.


LINKS:

Becky J. Mussat-Whitlow, M.A., Ph.D.
Statistician / Psychomatrician.
Director of Insititutional Assessment.
Division of Institutional Planning, Assessment, and Research.
Winston-Salem State University.
Winston-Salem, NC.

Richard D. Whitlow, M.A., J.D.
Patent and intellectual property law.
Jones Day.
Los Angeles, CA.

Profile at Advanced Neuroscience Imaging Research (ANSIR) Laboratory
Department of Radiologic Sciences
Wake Forest University School of Medicine
Winston-Salem, NC.


chris whitlow chris whitlow chris whitlow chris whitlow chris whitlow

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